Potassium chloride (KCl) injection is a critical electrolyte replacement used to treat or prevent severe hypokalemia. Its pharmacology centers on the regulation of the sodium-potassium ATPase pump, which maintains intracellular tonicity, nerve signaling, and muscle contraction. Because potassium dictates the resting membrane potential of cells, particularly in the heart, precise dosing and administration of KCl are vital to prevent life-threatening cardiac arrhythmias or cardiac arrest.