Leading Zopidaily 7.5 mg (Zopiclone) Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies Zopidaily 7.5 mg (Zopiclone) from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
Zopidaily 7.5 mg (Zopiclone), a non-benzodiazepine sedative-hypnotic of the cyclopyrrolone class used for the short-term treatment of insomnia. It works by enhancing the calming effects of gamma-aminobutyric acid (GABA) in the central nervous system.
Mechanism of Action : GABA Receptor Binding: Zopiclone acts as a full agonist at the benzodiazepine receptors (specifically the α-subunit of the (GABAA) receptor complex.
Neuronal Inhibition: This binding increases the frequency of chloride channel openings, allowing an influx of chloride ions that hyperpolarizes the neuron, resulting in sedation and suppression of the central nervous system.
Pharmacokinetics :
Absorption: It is rapidly absorbed after oral administration, reaching peak plasma concentrations within 30 to 60 minutes.
Metabolism: The drug is heavily metabolized in the liver primarily by CYP3A4 and CYP2C8 enzymes, creating inactive and weakly active metabolites.
Elimination: It has an average plasma elimination half-life of roughly 3.5 to 6 hours.
Excretion: Primarily excreted in urine (about 55%) and feces.
