City Drug House Exporters | Hepatitis Medicines Supplier to Washington, USA
City Drug House Exporters supplies and exports high-quality hepatitis medicines from India to Washington, USA with trusted pharma solutions and timely global delivery.
Velpaclear (400 mg sofosbuvir / 100 mg velpatasvir) is a fixed-dose antiviral medication used to treat chronic Hepatitis C (HCV) infections. It works by combining two distinct mechanisms of action to inhibit viral replication, boasting a cure rate (sustained virological response) exceeding 94%.
Mechanism of Action
The drug combines two direct-acting antivirals that target different stages of the Hepatitis C virus lifecycle:
Sofosbuvir (400 mg): A nucleotide analog that acts as a competitive inhibitor of the HCV NS5B RNA-dependent RNA polymerase. By doing this, it incorporates itself into the viral RNA chain, terminating its synthesis and halting viral replication.
Velpatasvir (100 mg): A pan-genotypic NS5A inhibitor. It blocks the NS5A protein, which is essential for viral replication and the assembly of new virus particles.
Pharmacokinetics
Administration: Taken orally, once daily, with or without food.
Absorption: Sofosbuvir is rapidly absorbed, reaching peak plasma levels in about 0.5 to 2 hours, with its active metabolite peaking at 2 to 4 hours. Velpatasvir reaches peak plasma concentrations approximately 3 hours post-dose.
Metabolism: Sofosbuvir is extensively metabolized in the liver to form the active pharmacologically active uridine nucleotide analog triphosphate (GS-461203). Velpatasvir is primarily metabolized in the liver by the cytochrome P450 (CYP) enzymes (CYP2B6, CYP2C8, and CYP3A4).
Elimination: Sofosbuvir and its metabolites are eliminated primarily by the kidneys (~80%) and feces (~14%). Velpatasvir is excreted mostly via biliary excretion (feces, ~94%) and minimally in urine (~0.4%).
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
City Drug House Exporters supplies and exports high-quality hepatitis medicines from India to Washington, USA with trusted pharma solutions and timely global delivery.
Velpaclear (400 mg sofosbuvir / 100 mg velpatasvir) is a fixed-dose antiviral medication used to treat chronic Hepatitis C (HCV) infections. It works by combining two distinct mechanisms of action to inhibit viral replication, boasting a cure rate (sustained virological response) exceeding 94%.
Mechanism of Action
The drug combines two direct-acting antivirals that target different stages of the Hepatitis C virus lifecycle:
Sofosbuvir (400 mg): A nucleotide analog that acts as a competitive inhibitor of the HCV NS5B RNA-dependent RNA polymerase. By doing this, it incorporates itself into the viral RNA chain, terminating its synthesis and halting viral replication.
Velpatasvir (100 mg): A pan-genotypic NS5A inhibitor. It blocks the NS5A protein, which is essential for viral replication and the assembly of new virus particles.
Pharmacokinetics
Administration: Taken orally, once daily, with or without food.
Absorption: Sofosbuvir is rapidly absorbed, reaching peak plasma levels in about 0.5 to 2 hours, with its active metabolite peaking at 2 to 4 hours. Velpatasvir reaches peak plasma concentrations approximately 3 hours post-dose.
Metabolism: Sofosbuvir is extensively metabolized in the liver to form the active pharmacologically active uridine nucleotide analog triphosphate (GS-461203). Velpatasvir is primarily metabolized in the liver by the cytochrome P450 (CYP) enzymes (CYP2B6, CYP2C8, and CYP3A4).
Elimination: Sofosbuvir and its metabolites are eliminated primarily by the kidneys (~80%) and feces (~14%). Velpatasvir is excreted mostly via biliary excretion (feces, ~94%) and minimally in urine (~0.4%).
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
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