Tevimbra 100 mg/10 mL vial (Tislelizumab) Exporter | India Supplier – City Drug Exporters Tevimbra 100 mg/10 mL vial (Tislelizumab).
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Tevimbra (tislelizumab) is a humanized monoclonal IgG4 antibody designed as an immune checkpoint inhibitor. It specifically targets and blocks Programmed Death Receptor-1 (PD-1), preventing it from binding with PD-L1 and PD-L2, which restores T-cell mediated antitumor responses.
Pharmacology Key Aspects :
1.Mechanism of Action: Blocks PD-1 to prevent interaction with ligands, enabling T-cell activation against tumor cells.
2.Key Feature: Engineered to reduce FcγR binding on macrophages, enhancing efficacy by limiting T-cell depletion.
3.Pharmacokinetics: Half-life is approximately 24 days, reaching steady-state in 12 weeks.
Indications
1.ESCC: First-line treatment for unresectable/metastatic Esophageal Squamous Cell Carcinoma in combination with chemotherapy.
2.Gastric Cancer: First-line for HER2-negative advanced gastric/gastroesophageal junction adenocarcinoma (with chemo).
3.NSCLC: Indicated for non-small cell lung cancer.
Important Safety Information :
1.Immune-Mediated Risks: Potential for severe reactions including pneumonitis, colitis, and hepatitis.
2.Side Effects: Common reactions include fatigue, musculoskeletal pain, nausea, and decreased blood counts.
3.Precautions: Requires embryo-fetal toxicity monitoring and 4.Refrigerated storage : Store in a refrigerator (2 - 8°C). Do not freeze.
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