City Drug House Exporters | Hepatitis Medicines Supplier to Washington, USA, INDIA
City Drug House Exporters supplies and exports high-quality hepatitis medicines from India to Washington, USA with trusted pharma solutions and timely global delivery.
Tafero 25mg contains Tenofovir alafenamide (TAF), a novel, targeted prodrug of tenofovir. It is an antiviral medication primarily used to treat chronic Hepatitis B and, in combination with other antiretrovirals, HIV-1 infection.
Mechanism of Action
Tenofovir alafenamide is a Nucleoside Reverse Transcriptase Inhibitor (NRTI).
Cellular Targeting: Unlike older drugs like tenofovir disoproxil fumarate (TDF), TAF remains stable in plasma. It diffuses passively into target cells (such as hepatocytes and CD4+ immune cells), where intracellular enzymes (like Cathepsin A) activate it.
Viral Inhibition: Inside the cell, the prodrug transforms into the active metabolite tenofovir diphosphate. This active form competes with natural substrates to inhibit viral polymerases (for HBV) and reverse transcriptase (for HIV), which halts viral DNA synthesis and replication.
Pharmacokinetics
Administration: 25mg taken orally once daily. It can be taken with or without food, although a high-fat meal may slightly increase absorption.
Bioavailability: High intracellular concentration is achieved while maintaining significantly lower tenofovir plasma concentrations compared to TDF.
Metabolism: Primarily metabolized intracellularly and in the liver by cathepsin A (to tenofovir) and carboxylesterase 1.
Excretion: Primarily eliminated via the kidneys, but because it avoids high systemic circulation, it causes much less renal and bone toxicity than older tenofovir formulations.
Clinical Considerations & Side Effects
Toxicity Profile: TAF provides high antiviral efficacy at a much lower dose than TDF, resulting in better bone mineral density preservation and lower rates of renal impairment.
Common Side Effects: Headache, diarrhea, nausea, fatigue, and abdominal pain.
Important Warning: Treatment can cause lactic acidosis, severe hepatomegaly with steatosis, or acute exacerbations of Hepatitis B if the medication is suddenly discontinued. Always consult an infectious disease or hepatology specialist for ongoing management.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
