City Drug House Exporters | Hepatitis Medicines Supplier to Washington, USA, INDIA
City Drug House Exporters supplies and exports high-quality hepatitis medicines from India to Washington, USA with trusted pharma solutions and timely global delivery.
Sofovir 400 is an antiviral medication containing sofosbuvir, a direct-acting antiviral (DAA) used to treat chronic Hepatitis C. As a nucleotide polymerase inhibitor, it blocks viral replication by disabling the RNA polymerase enzyme necessary for the Hepatitis C virus (HCV) to multiply.
Mechanism of Action
Prodrug Activation: Sofosbuvir is a prodrug. Once ingested, it is absorbed and converted into its pharmacologically active form, the uridine analog triphosphate (GS-461203).
Chain Termination: The active metabolite binds to the HCV NS5B (non-structural protein 5B) RNA-dependent RNA polymerase. It acts as a defective substrate, incorporating itself into the viral RNA and functioning as a chain terminator to stop HCV transcription and replication.
Barrier to Resistance: Because it targets the highly conserved active site of the polymerase, it boasts a high barrier to the development of viral resistance.
Pharmacokinetics :
Administration: Taken orally, typically at a dose of 400 mg once daily, and always combined with other antiviral agents (like ribavirin or ledipasvir) depending on the HCV genotype. It should be taken with food to decrease potential side effects like nausea.
Absorption: It absorbs rapidly, reaching peak plasma concentrations within 0.5 to 2 hours post-dose.
Metabolism: Metabolized primarily in the liver to form the pharmacologically inactive nucleoside metabolite (GS-331077).
Excretion: Primarily eliminated via the kidneys, with roughly 80% recovered in urine.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
