City Drug House Exporters | Hepatitis Medicines Supplier to Washington, USA, INDIA
City Drug House Exporters supplies and exports high-quality hepatitis medicines from India to Washington, USA with trusted pharma solutions and timely global delivery.
Sofocure V is a direct-acting fixed-dose antiviral combination (sofosbuvir 400 mg and velpatasvir 100 mg) used to treat chronic Hepatitis C Virus (HCV) infection. It stops the virus from replicating, clearing the infection in over 95 % of cases, typically over a 12-week course.
Sofosbuvir (400 mg) : A nucleotide analog HCV polymerase inhibitor. It acts as a 'false substrate' that incorporates into the viral RNA chain during replication, terminating chain extension.
Velpatasvir (100 mg ): An HCV NS5A inhibitor. It targets the NS5A protein, which is crucial for both RNA replication and the assembly of the viral core.
Pharmacokinetics :
Administration: Available as an oral tablet, with or without food.
Absorption: Sofosbuvir is rapidly absorbed, peaking in the blood within 0.5 to 2 hours. Velpatasvir reaches peak concentrations around 3 hours post-dose.
Metabolism: Sofosbuvir is extensively metabolized in the liver into its active, triphosphate form (the and GS-461203). Velpatasvir is primarily metabolized in the liver by CYP2B6, CYP2C8, and CYP3A4.
Excretion: Primarily excreted via feces (sofosbuvir) and biliary excretion (velpatasvir).
Drug Interactions & Safety :
Avoid Acid Reducers: Concomitant use with proton pump inhibitors (e.g., omeprazole) and H2-blockers (e.g., famotidine) can significantly reduce velpatasvir absorption and treatment efficacy.
Cardiac Risk: Co-administration with amiodarone may cause severe symptomatic bradycardia.
Common Side Effects: Include headache, fatigue, nausea, and diarrhea
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
City Drug House Exporters supplies and exports high-quality hepatitis medicines from India to Washington, USA with trusted pharma solutions and timely global delivery.
Sofocure V is a direct-acting fixed-dose antiviral combination (sofosbuvir 400 mg and velpatasvir 100 mg) used to treat chronic Hepatitis C Virus (HCV) infection. It stops the virus from replicating, clearing the infection in over 95 % of cases, typically over a 12-week course.
Sofosbuvir (400 mg) : A nucleotide analog HCV polymerase inhibitor. It acts as a 'false substrate' that incorporates into the viral RNA chain during replication, terminating chain extension.
Velpatasvir (100 mg ): An HCV NS5A inhibitor. It targets the NS5A protein, which is crucial for both RNA replication and the assembly of the viral core.
Pharmacokinetics :
Administration: Available as an oral tablet, with or without food.
Absorption: Sofosbuvir is rapidly absorbed, peaking in the blood within 0.5 to 2 hours. Velpatasvir reaches peak concentrations around 3 hours post-dose.
Metabolism: Sofosbuvir is extensively metabolized in the liver into its active, triphosphate form (the and GS-461203). Velpatasvir is primarily metabolized in the liver by CYP2B6, CYP2C8, and CYP3A4.
Excretion: Primarily excreted via feces (sofosbuvir) and biliary excretion (velpatasvir).
Drug Interactions & Safety :
Avoid Acid Reducers: Concomitant use with proton pump inhibitors (e.g., omeprazole) and H2-blockers (e.g., famotidine) can significantly reduce velpatasvir absorption and treatment efficacy.
Cardiac Risk: Co-administration with amiodarone may cause severe symptomatic bradycardia.
Common Side Effects: Include headache, fatigue, nausea, and diarrhea
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
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