City Drug House Exporters | Hepatitis Medicines Supplier to Washington, USA, INDIA
City Drug House Exporters supplies and exports high-quality hepatitis medicines from India to Washington, USA with trusted pharma solutions and timely global delivery.
Rivofonet (Tenofovir disoproxil fumarate) is an antiviral medication classified as a nucleotide analog reverse transcriptase inhibitor (nRTI). It is used in combination with other agents to treat HIV-1 and chronic Hepatitis B infections by halting viral multiplication.
Mechanism of Action
Action: Tenofovir disoproxil fumarate is a prodrug that is converted to tenofovir in the body. It competes with natural deoxyribonucleotides for incorporation into the growing viral DNA chain.
Target: It blocks the activity of HIV reverse transcriptase and Hepatitis B (HBV) DNA polymerase, causing premature chain termination and stopping viral replication.
Pharmacokinetics
Absorption: It is rapidly absorbed after oral administration. Taking the tablet with a high-fat meal increases its oral bioavailability and absorption rate.
Metabolism: It converts to the active form tenofovir via diester hydrolysis. It undergoes minimal hepatic metabolism (does not significantly interact with the cytochrome P450 enzyme system).
Excretion: It is primarily eliminated by the kidneys via a combination of glomerular filtration and active tubular secretion.
Clinical Indications
HIV-1: Used alongside other antiretroviral medications in adults and children.
Hepatitis B (HBV): Used for the long-term management of chronic HBV.
Precautions & Side Effects:
Common Side Effects: Nausea, vomiting, diarrhea, headache, fatigue, rash, and flatulence.Renal and Bone
Considerations: Because of its renal excretion pathway, it can cause or worsen kidney function issues. Long-term use is associated with a decrease in bone mineral density.
Lactic Acidosis: Like other NRTIs, it carries a risk of causing lactic acidosis and severe hepatomegaly with steatosis.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
