City Drug House Exporters | Hepatitis Medicines Supplier to Washington, USA, INDIA
City Drug House Exporters supplies and exports high-quality hepatitis medicines from India to Washington, USA with trusted pharma solutions and timely global delivery.
Resof Total 400mg/100mg Tablet is a fixed-dose combination antiviral medication used to treat chronic Hepatitis C virus (HCV) infection. It contains Sofosbuvir (400mg), a nucleotide analog NS5B polymerase inhibitor, and Velpatasvir (100mg), a pangenotypic NS5A inhibitor.
Mechanism of Action :
The combination works synergistically to disrupt the replication and assembly of the Hepatitis C virus at multiple stages:
Sofosbuvir: It acts as a defective nucleotide building block. Once inside infected cells, it is phosphorylated into its active form and incorporated into the viral RNA chain by the NS5B polymerase enzyme, which terminates chain synthesis and halts viral replication.
Velpatasvir: It inhibits the NS5A protein, a crucial phosphoprotein required by the virus for both RNA replication and the assembly of new virus particles.
Pharmacokinetics :
Absorption: Both drugs are readily absorbed, with peak plasma concentrations typically reached within 0.5 to 3 hours for Sofosbuvir and 3 hours for Velpatasvir.
Metabolism: Sofosbuvir undergoes extensive metabolism in the liver to form the pharmacologically active nucleoside analog triphosphate. Velpatasvir is primarily metabolized in the liver via the CYP3A4, CYP2C8, and CYP2B6 enzymes.
Excretion: Sofosbuvir and its active metabolite are primarily excreted in the urine. Velpatasvir is predominantly excreted in the feces, with a smaller fraction eliminated in the urine.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
