Leading Nitib 140 mg Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies Nitib 140 mg from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
Nitib 140 mg is a targeted anti-cancer medication that contains the active ingredient ibrutinib. It is primarily classified as a Bruton's Tyrosine Kinase (BTK) inhibitor. It works by irreversibly blocking the BTK protein, which disrupts the survival and growth signals needed by malignant B-cells. This targeted mechanism interrupts disease progression in specific types of leukemia and lymphoma.
Mechanism of Action :
BTK Inhibition: Ibrutinib forms a covalent bond with a cysteine residue in the BTK active site. This irreversibly blocks BTK activity.
Disrupts B-Cell Signaling: BTK is a crucial signaling molecule in the B-cell antigen receptor (BCR) pathway. Blocking it deprives cancerous B-cells of the survival signals they need to multiply.
Apoptosis: Deprived of survival signals, the malignant lymphocytes cease proliferating and eventually die, reducing tumor size and disease burden.
Pharmacokinetics
Absorption: The drug is administered orally and is rapidly absorbed. Peak plasma levels are typically reached within 1 to 2 hours of ingestion.
Protein Binding: It exhibits extensive binding to human plasma proteins (approximately 97%).
Metabolism: It is heavily metabolized in the liver, primarily by the cytochrome P450 enzyme system, predominantly CYP3A4. It has a minor active metabolite, PCI-45227, which also shows BTK-inhibiting activity.
Steady-State: Consistent drug levels in the blood are usually established within 8 days of once-daily dosing.
Dosage and Administration
Standard Dose: The typical dose is 420 mg to 560 mg once daily, depending on the specific condition being treated. This equates to 3 to 4 capsules of the Nitib 140 mg dose taken simultaneously.
Timing: The medication is generally taken at the same time every day with a glass of water.
Monitoring: Patients usually require regular blood cell count and liver function monitoring.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
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