Leading Metocan Injection (Metoclopramide Hydrochloride) Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies Metocan Injection (Metoclopramide Hydrochloride) from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
Metocan Injection (Metoclopramide Hydrochloride) is a dual-action antiemetic and gastroprokinetic pharmaceutical. It is primarily utilized to prevent severe post-operative and chemotherapy-induced nausea and vomiting, and to stimulate upper gastrointestinal (GI) motility.
Mechanism of Action : Metoclopramide operates through both central and peripheral nervous system pathways:
Antiemetic Effect: It blocks dopamine (D₂) receptors in the chemoreceptor trigger zone (CTZ) in the medulla, which halts the signals that trigger the vomiting center. At higher doses, it also acts as an antagonist at serotonin (5-HT₃) receptors in the brain.
Prokinetic Effect: It sensitizes tissues in the upper GI tract to acetylcholine and acts as a serotonin (5-HT₄) receptor agonist. This increases esophageal sphincter tone, enhances the amplitude of gastric contractions, and relaxes the pyloric sphincter, which accelerates gastric emptying.
Pharmacokinetics :
The pharmacology features of the drug when administered intravenously (IV) or intramuscularly (IM) are distinct:
Onset of Action: Very rapid; begins within 1 to 3 minutes following an IV dose and 10 to 15 minutes after an IM injection.
Metabolism: Primarily metabolized in the liver into sulfate and glucuronide conjugates.
Excretion: Primarily excreted in the urine (about 20% unchanged, with the remainder as conjugates).
Half-Life: The plasma elimination half-life is approximately 5 to 6 hours, but can extend to 14 hours or more in patients with severe renal impairment.
Adverse Effects & Precautions :
Metoclopramide carries significant neurological and systemic risks that require careful monitoring by healthcare providers:
Extrapyramidal Symptoms (EPS): Can cause involuntary muscle spasms, facial tics, or torticollis, particularly in children and young adults.
Tardive Dyskinesia: A potentially irreversible condition involving repetitive, involuntary body movements; long-term use should be avoided.
Sedation: Causes dose-dependent drowsiness and may result in additive effects when combined with alcohol, sedatives, or opioids.
Contraindications: Should not be used in patients with GI obstruction, perforation, hemorrhage, pheochromocytoma, or a history of seizure disorders.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
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