Leading Melostome tablets Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies Melostome tablets from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
Melostome tablets (often manufactured by Liv Bio Pharma) are a dietary supplement used to regulate the sleep-wake cycle and reduce anxiety. They combine natural hormones, amino acids, and herbal extracts to promote relaxation, decrease sleep latency, and ease mental stress.
Pharmacological
Mechanism of Action
The formulation relies on a synergistic blend of ingredients that act on multiple neurological and endocrine pathways in the central nervous system:
Melatonin (5 mg): A hormone that binds to MT₁ and MT₂ receptors in the brain's suprachiasmatic nucleus (SCN). This interaction suppresses wake-promoting signals, lowers body temperature, and signals to the body that it is time to rest.
GABA (100 mg): Gamma-aminobutyric acid is the primary inhibitory neurotransmitter in the brain. It binds to (GABA- A) receptors, which increases chloride ion influx, hyperpolarizing neurons and dampening central nervous system excitability to promote deep sleep.
Suntheanine® / L-Theanine (50 mg): An amino acid found naturally in tea leaves that crosses the blood-brain barrier. It elevates levels of inhibitory neurotransmitters (GABA, serotonin, and dopamine) while blocking glutamate receptors, thereby promoting an alert state of calmness and reducing stress-induced heart rate.
Valerian Root Extract (50 mg): Contains active compounds (such as valerenic acid) that inhibit the enzyme responsible for GABA breakdown. This effectively increases the amount of GABA available in the synaptic cleft, exerting mild sedative and anxiolytic properties.
Ashwagandha Extract (250 mg): An adaptogen that modulates the hypothalamic-pituitary-adrenal (HPA) axis. By lowering serum cortisol levels, it helps mitigate the physiological impacts of chronic stress and anxiety on the body.
Shankhpushpi (150 mg): A traditional Ayurvedic herb. Pharmacologically, it acts as a nootropic and brain tonic to reduce mental fatigue, enhance cognitive readiness, and ease transitions into restful sleep.
Aquamin® Mg TG / Elemental Magnesium (50 mg): Magnesium acts as a natural NMDA receptor blocker and muscle relaxant. It supports nerve function and reduces physical restlessness.
Pharmacokinetics
Onset: Taken 30 to 60 minutes prior to bedtime, the combined ingredients begin to exert a calming effect as blood plasma concentrations rise.
Metabolism: The primary active components like melatonin are metabolized rapidly by hepatic cytochrome P450 enzymes (specifically CYP1A2).Half-Life: Melatonin has a very short circulator
Half-life (t- 1/2) = 20 - 40 minutes. However, the inclusion of GABA, L-theanine, and herbal extracts provides sustained relaxation effects throughout the night
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
