Leading Lignocan-ADR 30 ml Injection Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies Lignocan-ADR 30 ml Injection from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
Lignocaine (Lidocaine) is a potent amino-amide local anesthetic and Class 1b antiarrhythmic drug. The 'ADR' in clinical pharmacology denotes its use alongside Adrenaline (epinephrine) to significantly prolong anesthetic duration, limit systemic absorption, and reduce localized bleeding.
Mechanism of Action:
Nerve Blockade: Lignocaine prevents pain signal transmission by reversibly blocking fast voltage-gated sodium channels on nerve cell membranes.
Antiarrhythmic: It stabilizes the cardiac action potential by blocking sodium channels in the His-Purkinje system, shortening the refractory period.
Vasoconstriction: Added adrenaline stimulates alpha-adrenergic receptors, causing localized blood vessel constriction.
Prolonged Effect: Constriction traps lignocaine at the injection site, slowing systemic uptake and extending its duration of action.
Pharmacokinetics
Onset: Rapid (3 to 5 minutes) when infiltrated or used for nerve blocks.
Metabolism: Primarily metabolized in the liver by CYP1A2 and CYP3A4 enzymes into active metabolites (MEGX and GX).
Excretion: Approximately 90% is excreted by the kidneys, though mostly as inactive metabolites.
Half-Life: Approximately 1.5 to 2 hours, but it may be prolonged in patients with heart or liver impairment.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
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📦 Business Type: Exporter | Bulk Supplier | Distributor
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