Leucorin 15 Mg Tablet (Calcium Folinate) Exporter | India Supplier – City Drug Exporters Leucorin 15 Mg Tablet (Calcium Folinate).
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1.Mechanism of Action: Leucovorin (Calcium Folinate) is an active, reduced form of folic acid. It works by providing the necessary folate that allows normal cells to survive the toxic effects of methotrexate, which works by blocking folic acid and inhibiting cell growth.
2.'Rescue' Function: It is used as a rescue agent to prevent the toxic side effects of methotrexate on healthy tissues.
3.Combination Treatment: It is used alongside 5-fluorouracil (5-FU) in colorectal cancer to enhance the cytotoxic action of the chemotherapy.
4.Antidote: It works as an antidote to counteract high-dose methotrexate therapy, folate deficiency anemia, and unintentional overdoses of folic acid antagonists.
Key Therapeutic Indications :
1.Methotrexate Rescue: To reduce the toxic effect of methotrexate.
2.Folate Deficiency Anemia: To treat megaloblastic anemia arising from folate deficiency.
3.Overdose Treatment: Used in cases of unintentional overdose of folic acid antagonists (e.g., trimethoprim, pyrimethamine).
4.Cancer Treatment Enhancement: In combination with 5-fluorouracil for advanced colorectal cancer.
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