City Drug House Exporters | Hepatitis Medicines Supplier to Washington, USA, INDIA
City Drug House Exporters supplies and exports high-quality hepatitis medicines from India to Washington, USA with trusted pharma solutions and timely global delivery.
Ledihep is a fixed-dose oral antiviral medication that combines (90 mg) of ledipasvir and (400 mg ) of sofosbuvir. It is prescribed for adults and children (3 years and older) to permanently clear chronic Hepatitis C virus (HCV) infections.
Mechanism of Action :L
Ledihep is a combination of two direct-acting antiviral (DAA) agents that target the Hepatitis C virus at multiple stages of its lifecycle:
Ledipasvir: Inhibits the viral NS5A phosphoprotein. This protein is essential for both the replication complex of the virus and the assembly of new viral particles.
Sofosbuvir: Acts as a nucleotide analog inhibitor of the viral NS5B RNA-dependent RNA polymerase. Once incorporated into the viral RNA chain, it causes chain termination, directly preventing the virus from replicating its genetic material.
Pharmacokinetics
Bioavailability & Absorption: Ledipasvir exhibits limited solubility, while sofosbuvir is rapidly absorbed.
Food Effect: The bioavailability of both drugs can increase when taken with a moderate-to-high-fat meal, but they can be taken with or without food.
Metabolism: Sofosbuvir is heavily metabolized in the liver to form the active triphosphate metabolite (GS-461203). Ledipasvir undergoes minor oxidative metabolism (though its primary route of excretion is unchanged in feces).
Excretion: Ledipasvir is primarily eliminated via feces (approximately 86%), with minor amounts in urine. Sofosbuvir and its inactive metabolite are predominantly excreted in urine (about 80%).
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
