City Drug House Exporters | Hepatitis Medicines Supplier to Washington, USA, INDIA
City Drug House Exporters supplies and exports high-quality hepatitis medicines from India to Washington, USA with trusted pharma solutions and timely global delivery.
Ledifos is a fixed-dose, oral antiviral medication combining Ledipasvir (90 mg) and Sofosbuvir (400 mg) . It is primarily used to treat chronic Hepatitis C (HCV) infections by halting viral replication within the liver.
Mechanism of Action :
Ledifos attacks the Hepatitis C virus (HCV) via a dual-action antiviral
Mechanism:Ledipasvir: Acts as an HCV NS5A inhibitor. It binds to the viral phosphoprotein NS5A, which is critical for RNA replication and viral assembly, disrupting its function and halting the production of new viruses.
Sofosbuvir: Acts as a nucleotide analog inhibitor of the HCV NS5B RNA-dependent RNA polymerase. It integrates directly into the viral RNA chain during replication, terminating the chain prematurely.
Pharmacokinetics
Administration: Taken orally once daily, with or without food.
Absorption: Both drugs have specific absorption rates, but their combination efficiently reaches peak systemic levels to inhibit viral loads.
Metabolism: Ledipasvir undergoes minor hepatic metabolism (mostly by CYP enzymes, though it is not a strong inhibitor/inducer of CYP3A4). Sofosbuvir is converted to its active triphosphate metabolite (GS-461203) in the liver and intestines.
Excretion: Both are excreted primarily via feces (for Ledipasvir, mainly as unchanged drug) and urine (for Sofosbuvir's metabolite)
Dosing & Indications
Indications: Used to treat HCV Genotypes 1, 4, 5, and 6 in adults and children.
Duration: Typically prescribed for 8 to 24 weeks based on the patient's viral load, genotype, and cirrhosis status.
Dosage: Standard adult dose is (90 mg ) Ledipasvir (400 mg ) Sofosbuvir once daily.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
