Leading Kamagra 100mg (Sildenafil citrate) Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies Kamagra 100mg (Sildenafil citrate) from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
Kamagra 100mg (Sildenafil citrate) as its active pharmaceutical ingredient. It belongs to the pharmacological class of phosphodiesterase type 5 (PDE5) inhibitors. The medication is used primarily to treat erectile dysfunction. It enhances the natural erectile response by increasing blood flow to the penis during sexual stimulation.
Mechanism of Action :
Sexual Stimulation: Triggers local release of nitric oxide (NO) in the corpus cavernosum.
Enzyme Activation: Nitric oxide activates the enzyme guanylate cyclase, increasing levels of cyclic guanosine monophosphate (cGMP).
Smooth Muscle Relaxation: Increased cGMP relaxes the smooth muscles in penile blood vessels, allowing blood to flow in.
PDE5 Inhibition: Sildenafil inhibits the PDE5 enzyme, which normally degrades cGMP.
Erection: Preventing the breakdown of cGMP maintains smooth muscle relaxation and engorgement of the penis.
Pharmacokinetics
Absorption: Rapidly absorbed after oral administration with an absolute bioavailability of roughly 40%.
Onset of Action: Works within 30 to 60 minutes. High-fat meals can delay the rate of absorption.
Distribution: Highly bound to plasma proteins (about 96%).
Metabolism: Primarily metabolized in the liver by cytochrome P450 enzymes (CYP3A4 and CYP2C9) into an active primary metabolite (N-desmethyl sildenafil).
Half-Life: Terminal elimination half-life is approximately 3 to 5 hours.
Excretion: Primarily excreted as metabolites in feces (about 80%) and urine (about 13%)
Indications and Usage :
Primary Use: Treatment of erectile dysfunction in adult men.
Recommended Dose: 50 mg taken as needed approximately 1 hour before sexual activity.
Maximum Dose: The dosage may be adjusted to 100 mg maximum based on tolerability and efficacy.
Frequency: Maximum recommended dosing is once per day.
Other Uses: Can also be prescribed for pulmonary arterial hypertension (PAH).
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
