Leading Hiforce 100 (sildenafil citrate), Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies (Hiforce 100 (sildenafil citrate) from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
Hiforce 100 (sildenafil citrate), an oral medication classified as a phosphodiesterase type 5 (PDE5) inhibitor. It is primarily used to treat erectile dysfunction by relaxing blood vessels and increasing blood flow to the penis during sexual stimulation.
Mechanism of Action :
Sexual Arousal: Physical or psychological stimulation is required to initiate the process.
Nitric Oxide Release: Arousal triggers the release of nitric oxide in the erectile tissue (corpus cavernosum).
cGMP Production: Nitric oxide activates an enzyme that produces cyclic guanosine monophosphate (cGMP).
Muscle Relaxation: cGMP relaxes the smooth muscles in the blood vessels, allowing blood to flow into the penis.
PDE5 Inhibition: Sildenafil inhibits the PDE5 enzyme, which typically breaks down cGMP.
Erection Maintenance: Preventing the breakdown of cGMP maintains elevated levels, keeping the blood vessels dilated to sustain an erection.
Pharmacokinetics '
Absorption: Rapidly absorbed after oral administration.
Bioavailability: Absolute bioavailability is roughly 41%.Onset of Action: Works within 30 to 60 minutes; onset can be delayed by a high-fat meal.
Peak Plasma Levels: Reached within 30 to 120 minutes in a fasted state.
Duration of Effect: Typically provides effectiveness for 4 to 6 hours, gradually tapering off.
Metabolism: Metabolized in the liver primarily by the CYP3A4 enzyme (major pathway) and CYP2C9 enzyme (minor pathway).Half-life: Terminal half-life is about 4 hours.
Excretion: Excreted mainly as metabolites in the feces (about 80%) and urine (about 13%).
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
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