Exporter India Herduo 250 mg tablet (Lapatinib)| Bulk Supply Oncology Drugs .
Buy Herduo 250 mg tablet (Lapatinib) in bulk from India. Leading oncology drug exporter City Drug House Exporters offering global supply with latest regulatory updates and competitive pricing.
Key Pharmacological Aspects :
Mechanism of Action
1.Dual Pathway Inhibition: Lapatinib inhibits both the HER2/ErbB2 and EGFR/ErbB1 (Epidermal Growth Factor Receptor) pathways.
2.Cancer Growth Suppression: By blocking these receptors, it interrupts downstream signaling, thereby slowing the multiplication of cancer cells and inducing apoptosis (cell death).
3.Specificity: It is particularly effective for cancer cells that overproduce HER2, which are common in specific advanced breast cancer types.
Therapeutic Uses
1.Metastatic HER2+ Breast Cancer: Indicated for HER2-positive breast cancer that has spread to other body parts (metastatic).
2.Combination Therapy: Generally used in combination with Capecitabine (for patients previously treated with anthracycline, taxane, and trastuzumab) or with Letrozole/Anastrozole (for hormone receptor-positive metastatic breast cancer).
Dosage and Administration
1Administration: Taken orally, usually once daily.
2.Dietary Guidance: Must be taken on an empty stomach, typically 1 hour before or 2 hours after a meal.
3.Precaution: Swallow the tablet whole; do not chew, crush, or break it.
Key Side Effects
1.Common: Diarrhea (frequently reported), nausea, vomiting, fatigue, rash, stomatitis (mouth sores), and hand-foot syndrome.
2.Serious: Hepatotoxicity (liver damage), cardiotoxicity (decreased left ventricular ejection fraction), interstitial lung disease, and severe cutaneous reactions.
Drug Interactions and Precautions
1.Contraindications: Not recommended for use during pregnancy (embryo-fetal toxicity) or breastfeeding.
2.Drug Interactions: Avoid strong CYP3A4 inhibitors (e.g., ketoconazole) and inducers (e.g., phenytoin).
3.Food Interaction: Avoid grapefruit and grapefruit juice, as they can increase the levels of the medication in the blood.
4.Monitoring: Regular monitoring of liver function (LFTs), heart function (LVEF), and blood pressure is required.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
