City Drug House Exporters | Hepatitis Medicines Supplier to Washington, USA, INDIA
City Drug House Exporters supplies and exports high-quality hepatitis medicines from India to Washington, USA with trusted pharma solutions and timely global delivery.
Daclahep (Daclatasvir), a direct-acting antiviral medication used to treat chronic Hepatitis C virus (HCV) infections. It operates as a highly specific HCV NS5A inhibitor, disrupting viral replication to lower viral loads and prevent liver damage.
Mechanism of Action (MOA)
Target: Binds to the HCV NS5A (Non-structural protein 5A).
Function: NS5A is a multifunctional phosphoprotein that is essential for both RNA replication and virus particle assembly. By inhibiting this protein, daclatasvir effectively stops the virus from multiplying and spreading to uninfected liver cells.
Pharmacokinetics :
Administration: Taken orally, usually in a dose of 60mg once daily.
Absorption: It is rapidly absorbed after oral administration, typically reaching peak plasma concentrations within 1 to 2 hours.
Metabolism: Metabolized in the liver primarily by the cytochrome P450 3A4 (CYP3A4) enzyme system.
Excretion: Primarily excreted via feces (~88 %) and to a lesser extent through urine (~ 6.6%).
Clinical Usage & Interactions
Combination Therapy: It is never used as a monotherapy. Daclahep is prescribed alongside other direct-acting antivirals, primarily sofosbuvir (with or without ribavirin), depending on the HCV genotype.
Drug Interactions: Because it relies on CYP3A4 for metabolism, concurrent use of strong CYP3A4 inducers (like rifampin, carbamazepine, or St. John's wort) can lower daclatasvir levels, potentially reducing its therapeutic effect.
Dosage Adjustments: Your doctor may adjust the dose if you are taking concurrent moderate CYP3A4 inhibitors (e.g., ketoconazole) or certain inducers.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
