Leading D-Pressin Nasal Spray 5 ml Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies D-Pressin Nasal Spray 5 ml from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
D-Pressin Nasal Spray 5 ml contains desmopressin acetate (0.01% w/v), a synthetic analogue of the natural human posterior pituitary hormone, arginine vasopressin. Its primary clinical use is as an antidiuretic hormone replacement to treat central cranial diabetes insipidus and to manage nocturnal enuresis (bed-wetting).
Mechanism of Action :
V2 Receptor Binding: It selectively binds to V₂ receptors located on the basolateral membranes of renal collecting duct cells.
cAMP Activation: Binding activates the enzyme adenylate cyclase, increasing intracellular cyclic AMP (cAMP).
Water Reabsorption: This cascade triggers the migration of aquaporin-2 water channels to the apical membrane.
Concentrated Urine: The membrane becomes highly permeable to water, allowing rapid reabsorption into the bloodstream.
Blood Clotting (Hemostatic): It stimulates the release of von Willebrand factor (vWF) and Factor VIII from endothelial cells, aiding in the management of specific bleeding disorders.
Pharmacokinetics :
Route of Administration: Intranasal administration provides rapid systemic absorption through the highly vascularized nasal mucosa.
Onset and Duration: It provides a prompt onset of antidiuretic action with a prolonged duration, reducing urine volume and significantly increasing urine osmolality.
Half-Life: Biphasic half-lives are approximately 7.8 minutes for the initial fast phase and 75.5 minutes for the slow elimination phase.
Metabolism: The exact degradation pathway in humans is not fully mapped, though it is primarily metabolized and cleared by the kidneys and liver.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
