Leading Cobra 120Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies Cobra 120 from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
Cobra 120 is a generic erectile dysfunction medication (120 mg of sildenafil citrate), an active pharmaceutical ingredient (API) belonging to the phosphodiesterase type 5 (PDE5) inhibitor class. It acts primarily by dilating blood vessels to increase blood flow to the penis during sexual stimulation. Cobra 120 is generally manufactured as a high-potency variant for patients unresponsive to standard 100 mg doses.
Mechanism of Action
PDE5 Inhibition: The enzyme PDE5 degrades cyclic guanosine monophosphate (cGMP) in the corpus cavernosum.
Smooth Muscle Relaxation: By inhibiting PDE5, sildenafil preserves cGMP levels, which relaxes the penile smooth muscle.
Vasodilation: Blood vessels dilate, facilitating increased blood flow and producing an erection.
Stimulation Dependency: The drug only facilitates an erection and will not work without physical or psychological sexual arousal.
Pharmacokinetics
Absorption: Rapidly absorbed after oral administration.
Onset: Effects generally begin within 30 to 60 minutes.
Duration: The clinical effects last typically between 4 to 6 hours.
Metabolism: Primarily metabolized in the liver by the cytochrome P450 3A4 (primary) and 2C9 (secondary) pathways.
Excretion: Cleared mainly through feces (about 80%) and urine (about 13%).
Contraindications & Interactions
Nitrates: Strictly contraindicated with nitrate medications (e.g., nitroglycerin) or nitric oxide donors. The combination can cause fatal drops in blood pressure.
Cardiovascular Disease: Contraindicated in patients with severe heart disease or recent cardiac events.
Drug Interactions: Do not combine with other PDE5 inhibitors, alpha-blockers, or strong CYP3A4 inhibitors like ritonavir.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
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📦 Business Type: Exporter | Bulk Supplier | Distributor
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