Leading Borviz 2mg Injection (Bortezomib) Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies Borviz 2mg Injection (Bortezomib) from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
Borviz 2mg Injection (Bortezomib) is an antineoplastic agent used to treat multiple myeloma and mantle cell lymphoma. It works as a reversible proteasome inhibitor. By blocking the cellular 'trash disposal system' (the 26S proteasome), it causes a toxic buildup of proteins inside the cancer cell, eventually leading to programmed cell death (apoptosis).
Mechanism of Action :
Proteasome Inhibition: Reversibly inhibits the 26S proteasome complex.
Protein Buildup: Prevents the degradation of misfolded or regulatory proteins.
Cellular Stress: Triggers endoplasmic reticulum (ER) stress and activates apoptotic pathways.
Disrupted Signaling: Blocks survival pathways (like the NF-κB pathway) cancer cells rely on.
Pharmacodynamics
Target Cells: Highly specific to plasma cells, though it impacts various cellular processes.
Synergy: Sensitizes therapy-resistant cancer cells to standard alkylating agents and corticosteroids.
Physiological Effect: Induces cell cycle arrest and apoptosis in both newly diagnosed and relapsed malignancies.
Pharmacokinetics
Administration: Given via intravenous (IV) push or subcutaneous (SC) injection.
Distribution: Highly bound to human plasma proteins (83% on average).
Metabolism: Primarily oxidized in the liver by cytochrome P450 enzymes (CYP3A4 and CYP2C19).
Excretion: Metabolites are primarily eliminated by the kidneys.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
