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A bifunctional alkylating agent used to treat chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL). It works by creating inter- and intra-strand crosslinks in DNA, disrupting transcription and inducing apoptosis (cell death) in cancerous cells.
Key Pharmacological Aspects:
1.Mechanism: As a nitrogen mustard derivative, it acts as an alkylating agent, damaging DNA/RNA in both resting and dividing tumor cells.
2.Administration: Given via intravenous (IV) infusion under professional supervision.
3.Common Side Effects: Bone marrow suppression (anemia, thrombocytopenia, neutropenia), nausea, vomiting, infection, and fatigue.
4.Precautions: Requires regular monitoring of blood counts and renal/hepatic function, as it may cause severe myelosuppression and infection.
5.It is not to be self-administered and is contraindicated in pregnant or breastfeeding .
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