Leading BDRelin 3.75 mg Injection (triptorelin) Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies BDRelin 3.75 mg Injection (triptorelin) from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
BDRelin 3.75 mg Injection (triptorelin) is a synthetic gonadotropin-releasing hormone (GnRH) agonist. It alters the hypothalamic-pituitary-gonadal axis to dramatically lower testosterone and estrogen levels. Clinically, it is utilized to treat hormone-dependent conditions such as prostate cancer, endometriosis, and central precocious puberty.
Mechanism of Action
Initial stimulation: The drug binds tightly to pituitary GnRH receptors, causing a temporary surge ('flare') of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Receptor downregulation: Continuous administration downregulates these receptors, eventually rendering the pituitary gland unresponsive.
Hormone suppression: The pituitary stops releasing LH and FSH, leading to a profound suppression of gonadal steroid hormones.
Pharmacokinetics
Administration: Administered as an intramuscular or subcutaneous depot injection, typically once every 28 days.
Metabolism: Undergoes degradation by peptidases primarily in the liver and kidneys; it lacks defined structural metabolites.
Half-life: Follows a 3-compartment pharmacokinetic model, with distribution and elimination half-lives of roughly 6 minutes, 45 minutes, and 3 hours.
Adverse Effects & Precautions
Flare reaction: The initial surge in sex hormones can temporarily worsen conditions (e.g., bone pain or urinary obstruction in prostate cancer) before suppression is achieved.
Hormonal side effects: Frequently includes hot flashes, reduced libido, and sexual dysfunction.
Bone health: Long-term suppression lowers bone mineral density, putting patients at risk for osteoporosis and fractures.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
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https://www.citydrugexporters.com
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📦 Business Type: Exporter | Bulk Supplier | Distributor
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