Leading Acetylcysteine injection (N-acetylcysteine or NAC) Supplier from INDIA to Washington, USA | City Drug Exporters
City Drug Exporters supplies Acetylcysteine injection (N-acetylcysteine or NAC) from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
Acetylcysteine injection (N-acetylcysteine or NAC) is primarily used as a potent antidote to prevent severe liver damage following an acetaminophen (paracetamol) overdose. It functions as a glutathione precursor, supplying the liver with necessary substrates to detoxify the harmful metabolic byproducts of acetaminophen.
Pharmacology :
Mechanism of Action: When acetaminophen is metabolized, it produces a toxic byproduct called NAPQI. Normally, NAPQI is detoxified by the liver's natural glutathione reserves. During an overdose, these reserves are depleted. Acetylcysteine acts as a prodrug for L-cysteine, restoring intracellular glutathione (GSH) levels so the liver can neutralize NAPQI.
Antioxidant Effect: It acts as a direct reactive oxygen species (ROS) scavenger and provides sulfhydryl groups, which help modulate the cellular redox status and prevent oxidative damage.
Pharmacokinetics: When administered intravenously, NAC quickly distributes into the body and is metabolized in the liver into cysteine and subsequently into glutathione, sulfates, and other products. It has a short half-life of roughly 2 to 6 hours.
Typical Dosing Protocol (IV)
For adults, it is traditionally given intravenously over a 21-hour period using a standardized regimen:
Loading Dose: 150 mg/kg diluted in 200 mL of diluent (e.g., 5% Dextrose or 0.9% Saline), administered over the first hour.
Second Dose: 50 mg/kg diluted in 500 mL over the next 4 hours.
Maintenance Dose: 100 mg/kg diluted in 1000 mL over the final 16 hours.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
City Drug Exporters supplies Acetylcysteine injection (N-acetylcysteine or NAC) from INDIA to Washington, USA. Trusted pharmaceutical exporter for wholesalers, distributors, pharmacies, and healthcare procurement companies
Acetylcysteine injection (N-acetylcysteine or NAC) is primarily used as a potent antidote to prevent severe liver damage following an acetaminophen (paracetamol) overdose. It functions as a glutathione precursor, supplying the liver with necessary substrates to detoxify the harmful metabolic byproducts of acetaminophen.
Pharmacology :
Mechanism of Action: When acetaminophen is metabolized, it produces a toxic byproduct called NAPQI. Normally, NAPQI is detoxified by the liver's natural glutathione reserves. During an overdose, these reserves are depleted. Acetylcysteine acts as a prodrug for L-cysteine, restoring intracellular glutathione (GSH) levels so the liver can neutralize NAPQI.
Antioxidant Effect: It acts as a direct reactive oxygen species (ROS) scavenger and provides sulfhydryl groups, which help modulate the cellular redox status and prevent oxidative damage.
Pharmacokinetics: When administered intravenously, NAC quickly distributes into the body and is metabolized in the liver into cysteine and subsequently into glutathione, sulfates, and other products. It has a short half-life of roughly 2 to 6 hours.
Typical Dosing Protocol (IV)
For adults, it is traditionally given intravenously over a 21-hour period using a standardized regimen:
Loading Dose: 150 mg/kg diluted in 200 mL of diluent (e.g., 5% Dextrose or 0.9% Saline), administered over the first hour.
Second Dose: 50 mg/kg diluted in 500 mL over the next 4 hours.
Maintenance Dose: 100 mg/kg diluted in 1000 mL over the final 16 hours.
City Drug House Exporters provides:
Bulk supply for hospitals & distributors
Export to USA. Washington, INDIA
Regulatory documents (COA, MSDS, etc.)
Competitive pricing & reliable logistics
Contact for More Information :
📞 Contact City drug House Exporters from India
🌐 Websites:
https://www.citydrugexporters.com
📧 Email: citydrug123@gmail.com
📦 Business Type: Exporter | Bulk Supplier | Distributor
📲 WhatsApp: +91 9975390171
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