2 baconil TTS10 Nicotine Transdermal Patches (7mg/24 hrs) Exporter | India Supplier – City Drug Exporters 2 baconil TTS10 Nicotine Transdermal Patches (7mg/24 hrs) from India.
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Pharmacology of 7 mg/24h Nicotine Patch
1.Mechanism of Action: Nicotine acts as an agonist at nicotinic-cholinergic receptors in the central and peripheral nervous system. By binding to these receptors—specifically in the brain's reward system—the patch mimics the effects of tobacco nicotine to reduce cravings and withdrawal symptoms such as anxiety, irritability, and restlessness.
2.Pharmacokinetics (Absorption & Delivery): The patch provides a sustained, slow-release of nicotine, avoiding the sharp nicotine surges associated with smoking. Following application, there is a slight delay (1-2 hours), followed by a progressive rise in plasma nicotine concentrations, reaching a plateau at about 8-10 hours.
3.Systemic Availability: Approximately 68% to 76.8% of the nicotine released from the patch is systemically available, with the remainder lost through evaporation.
4.Metabolism & Elimination: Nicotine is primarily metabolized in the liver to cotinine (which has a longer half-life of ~16 hours). The half-life of nicotine itself is about 1 to 2 hours. It is excreted via the kidneys.
5.Step-Down Therapy (7mg Usage): The 7mg patch is generally used as Step 3 in a 12-week, 3-step program. It is designed for the final phase of quitting, for individuals smoking less than 10 cigarettes a day, or as a step-down from higher-dose patches (21mg or 14mg).
Key Pharmacological Points & Warnings
1.24-Hour Release: The patch provides consistent, 24-hour relief, often recommended to manage morning cravings.
2.Contraindications: Should not be used by non-smokers, children under 18, or those with severe skin allergies.
3.Safety Warning: Do not use more than one patch at a time, as this can cause nicotine overdose, leading to nausea, vomiting, dizziness, or rapid heartbeat.
4.Side Effects: Common side effects include skin irritation at the application site (erythema/pruritus), insomnia, and vivid dreams.
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